Cutler has the easier matchup but I don't think he'll pass a ton with the run working. McNabb will have less time to throw but will get to toss it around more. It's close but I'd give the edge to McNabb since I see alot of quick passes to Westbrook to counter the Giants' pass rush.
Reggie Bush has your best matchup at RB but has a PCL injury and it's looking like he won't play. Fargas has a crappy matchup but should get the ball more than Taylor or Watson so I'd start him. Taylor should see more carries than Watson and I'd expect the Vikings to run as much as possible against the Niners.